CD53(63-5A3), CF405S conjugate, 0.1mg/mL [26628-22-8]

Biotium

CD53(63-5A3), CF405S conjugate, 0.1mg/mL

9

Functional Assay, Flow Cytometry, ImmunoPrecipitation

Research Use Only

Monoclonal

63-5A3

0.1 mg/ml

Other Conjugate

CD53

CD53 molecule

antigen MOX44 identified by monoclonal antibody MRC-OX44; CD53 antigen; CD53 glycoprotein; CD53 tetraspan antigen; cell surface antigen; cell surface glycoprotein CD53; leukocyte surface antigen CD53; MOX44; tetraspanin-25; transmembrane glycoprotein; TSPAN25; tspan-25

Mouse

IgG2b

Leukocyte surface antigen CD53

Recognizes a protein of 33-55 kDa, identified as CD53 (Workshop V; Code CD53.1). CD53 is expressed on monocytes, and macrophages, granulocytes, dendritic cells, osteoblasts and osteoclasts, NK cells, and on T- and B-cells from every stage of differentiation but is absent from platelets, erythrocytes, and non-haemopoietic cells. CD53 is a member of a family of tetraspan transmembrane proteins, including CD9, CD37, CD63, CD81, and CD82. It associates with integrins, MHC class II molecules, and a tyrosine phosphatase and plays a role in cellular activation as part of a signal transduction complex involving other membrane glycoproteins. Defects of CD53 expression on neutrophils appear to be related with recurrent infectious diseases. Cross-linking CD53 using CD53 antibodies led to cytoplasmic calcium fluxes in B cells, monocytes, and granulocytes and activation of the monocyte oxidative burst.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Animal

2°C to 8°C

12352203