CD71 antibody [N2C1], Internal
GTX102596
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Product group Antibodies
TargetTFRC
Overview
- SupplierGeneTex
- Product NameCD71 antibody [N2C1], Internal
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.47 mg/ml
- ConjugateUnconjugated
- Gene ID7037
- Target nameTFRC
- Target descriptiontransferrin receptor
- Target synonymsCD71; IMD46; p90; T9; TFR; TFR1; TR; transferrin receptor protein 1; TRFR
- HostRabbit
- IsotypeIgG
- Protein IDP02786
- Protein NameTransferrin receptor protein 1
- Scientific DescriptionCellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Inhibition of Indoxyl Sulfate-Induced Reactive Oxygen Species-Related Ferroptosis Alleviates Renal Cell Injury In Vitro and Chronic Kidney Disease Progression In Vivo.Read more
- Trophoblast Differentiation Affects Crucial Nutritive Functions of Placental Membrane Transporters. Karahoda R et al., 2022, Front Cell Dev BiolRead more
- African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin. Singh KS et al., 2020 Jan 24, Nat CommunRead more
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