ProductsBack/CD71 antibody [N2C1], Internal

CD71 antibody [N2C1], Internal

Name: CD71 antibody [N2C1], Internal
SKU: GTX102596_G10
Availability: BackOrder

GTX102596

ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry

Product group Antibodies

TargetTFRC

Overview

Supplier
GeneTex
Product Name
CD71 antibody [N2C1], Internal
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Certification
Research Use Only
Clonality
Polyclonal
Concentration
0.47 mg/ml
Conjugate
Unconjugated
Gene ID7037
Target name
TFRC
Target description
transferrin receptor
Target synonyms
CD71, IMD46, T9, TFR, TFR1, TR, TRFR, p90, transferrin receptor protein 1
Host
Rabbit
Isotype
IgG
Protein IDP02786
Protein Name
Transferrin receptor protein 1
Scientific Description
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Tsai LT, Weng TI, Chang TY, et al. Inhibition of Indoxyl Sulfate-Induced Reactive Oxygen Species-Related Ferroptosis Alleviates Renal Cell Injury In Vitro and Chronic Kidney Disease Progression In Vivo. Antioxidants (Basel). 2023,12(11). doi: 10.3390/antiox12111931
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Karahoda R, Zaugg J, Fuenzalida B, et al. Trophoblast Differentiation Affects Crucial Nutritive Functions of Placental Membrane Transporters. Front Cell Dev Biol. 2022,10:820286. doi: 10.3389/fcell.2022.820286
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Singh KS, Leu JI, Barnoud T, et al. African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin. Nat Commun. 2020,11(1):473. doi: 10.1038/s41467-019-14151-9
Read this paper