CD72 (B Cell Marker)(BU40), CF740 conjugate, 0.1mg/mL

Biotium

CD72 (B Cell Marker)(BU40), CF740 conjugate, 0.1mg/mL

16

ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

BU40

0.1 mg/ml

Other Conjugate

CD72

CD72 molecule

CD72b, LYB2, B-cell differentiation antigen CD72, CD72 antigen, lyb-2

IgG2a

B-cell differentiation antigen CD72

The C-type lectin superfamily member CD72 is a cell surface negative regulator of B cell activation from the pro-B through the mature B cell stage. CD72 serves as a receptor for CD5. The human CD72 gene encodes a transmembrane glycoprotein that contains an immunoreceptor tyrosine-based inhibition motif (ITIM). Upon tyrosine phosphorylation, the CD72 ITIM recruits SH2-containing phosphatases such as SHP-1, resulting in downregulation of cell activation. CD72-/- mice contain hyperproliferative B cells. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Animal

2°C to 8°C,RT

41116100