CD73 (Immuno-Oncology Target)(NT5E/2545), CF740 conjugate, 0.1mg/mL
BNC742545
ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Proteins / Signaling Molecules
Protein IDP21589
Overview
- SupplierBiotium
- Product NameCD73 (Immuno-Oncology Target)(NT5E/2545), CF740 conjugate, 0.1mg/mL
- Delivery Days Customer16
- ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDNT5E/2545
- Concentration0.1 mg/ml
- ConjugateOther Conjugate
- Gene ID4907
- Target nameNT5E
- Target description5'-nucleotidase ecto
- Target synonymsCALJA, CD73, E5NT, NT, NT5, NTE, eN, eNT, 5'-nucleotidase, 5'-NT, 5'-deoxynucleotidase, IMP-specific 5'-nucleotidase, Purine 5-Prime-Nucleotidase, ecto-5'-nucleotidase, thymidylate 5'-phosphatase
- IsotypeIgG1
- Protein IDP21589
- Protein Name5'-nucleotidase
- Scientific DescriptionCD73 (also designated ecto-5-nucleotidase, E5NT, NT, NT5, NTE, eN and eNT) is a glycosyl-phosphatidylinositol (GPI)-anchored adhesion protein that catalyzes the dephosphorylation of extracellular purine and pyrimidine nucleotides to their corresponding bioactive nucleosides. CD73 is a dimer of two identical subunits that depends on GPI to link with the external face of the plasma membrane. Similar to other GPI-anchored proteins, CD73 mediates co-stimulatory signals in T cell activation. CD73 has few structural variants, yet elicits diverse biological function through differential regulation in endothelial cells (EC), subpopulations of B and T cells, germinal center follicular dendritic cells and on thymic medullary reticular fibroblasts. For example, IgG mediated neutralization of CD73 interferes with lymphocyte adhesion to EC, and blocks aggregation of germinal center B cells and follicular dendritic cells. Furthermore, IgG-mediated targeting of lymphocyte CD73, but not of endothelial cell CD73, causes shedding of CD73 and tyrosine phosphorylation of proteins. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- SourceAnimal
- Storage Instruction2°C to 8°C,RT
- UNSPSC41116100