CD8 antibody [2ST8.5H7]

GeneTex

CD8 antibody [2ST8.5H7]

9

The antibody binds to the beta chain, recognising an epitope that is dependent upon expression of both CD8 alpha and CD8 beta.

FACS: Neat-1/10. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Flow Cytometry, ImmunoPrecipitation, Western Blot

Research Use Only

Monoclonal

2ST8.5H7

1 mg/ml

Unconjugated

CD8B

CD8b molecule

CD8 antigen, beta polypeptide 1 (p37); CD8B1; LEU2; LY3; LYT3; P37; T lymphocyte surface glycoprotein beta chain; T-cell surface glycoprotein CD8 beta chain

Mouse

IgG2a

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq, May 2010]

Human, Monkey, Primate

-20°C or -80°C,2°C to 8°C

12352203