Bio-Connect

CDK-IN-9

HY-150641
MedChem Express
Molecular Weight420.53
Product group Chemicals
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Overview

  • Supplier
    MedChem Express
  • Product Name
    CDK-IN-9 [3031561-92-6]
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Molecular Formula
    C21H24N8S
  • Molecular Weight
    420.53
  • Scientific Description
    CDK-IN-9 (compound 24) is a potent CDK inhibitor, also as a molecular glue inducing an interaction between CDK12 and DDB1, with an IC50 values of 4 nM for CDK2/E. CDK-IN-9 leads to polyubiquitination of cyclin K and its subsequent degradation. CDK-IN-9 induce apoptosis through dephosphorylation of retinoblastoma protein and RNA polymerase II[1].
  • SMILES
    NCCSC1=NC2=C(NN=C2C(NCC3=CC=C(C=C3)N4C=CC=N4)=N1)C5CCC5
  • UNSPSC
    12131703