Cdk1/2 Inhibitor III [443798-55-8]

MedChem Express

Cdk1/2 Inhibitor III [443798-55-8]

5

443798-55-8

Research Use Only

99.69

C15H13F2N7O2S2

425.44

Cdk1/2 Inhibitor III (compound 3n) is a highly potent and selective Cdk1/cyclin B and Cdk2/cyclin A inhibitor of with IC50s of 0.6 nM and 0.5 nM, respectively. Cdk1/2 Inhibitor III shows selectivity over VEGF-R2 (IC50 of 32 nM), GSK-3beta (IC50 of 140 nM), and a other kinases. Cdk1/2 Inhibitor III inhibits in cell proliferation with IC50s of 20 nM, 35 nM and 92 nM for HCT-116, HeLa, and A375 cells, respectively[1].

S=C(N1N=C(N)N=C1NC2=CC=C(S(=O)(N)=O)C=C2)NC3=C(F)C=CC=C3F

-20°C,2°C to 8°C

12352200