CDK1/2/4-IN-1 [2414633-49-9]

MedChem Express

CDK1/2/4-IN-1 [2414633-49-9]

10

2414633-49-9

Research Use Only

C15H16N2O2S

288.36

CDK1/2/4-IN-1 (compound 3a) is a potent CDK inhibitor with IC50 values of 1.47, 0.78 and 0.87 microM for CDK1, CDK2 and CDK4, respectively. CDK1/2/4-IN-1 arrests cell cycle at G2/M phase and induces apoptosis. CDK1/2/4-IN-1 elevates Bax, caspase-3, P53 levels and decreases Bcl-2 level. CDK1/2/4-IN-1 can be used for cancer research[1].

O=C(C1=C(C)SC(NC)=N1)/C=C/C2=CC=C(OC)C=C2

12131703