CDK4-IN-1 [1256963-02-6]

MedChem Express

CDK4-IN-1 [1256963-02-6]

5

1256963-02-6

Research Use Only

C22H29ClN8

440.97

CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM; 1500 and 500 fold than CDK1/Cyclin B (IC50>15 uM) and CDK2/Cyclin A (IC50=5.265 uM) respectively. IC50 Value: 10 nM (CDK4/Cyclin D1) [1] Target: CDK4 CDK4/6 inhibitor imposed a G1 block on cells at 0.37microM in the CDK4 Cellular Assays. CDK4/6 inhibitor exhibited the most sustained G1 arrest among five compounds and were tested further against a selection of serine-threonine and tyrosine kinases and proved to be selective for CDK4/6 over 35 other kinases [1].

CN(C1CCN(C2=CN=C(NC3=NC=CC(C4=C(Cl)NN=C4C(C)C)=N3)C=C2)CC1)C

12352200