CDK5R1 Antibody

Cusabio

CDK5R1 Antibody

20

ImmunoFluorescence, Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

CDK5R1

cyclin dependent kinase 5 regulatory subunit 1

CDK5P35, CDK5R, NCK5A, p23, p25, p35, p35nck5a, cyclin-dependent kinase 5 activator 1, CDK5 activator 1, TPKII regulatory subunit, neuronal CDK5 activator, regulatory partner for CDK5 kinase, tau protein kinase II 23kDa subunit

Rabbit

IgG

Cyclin-dependent kinase 5 activator 1

p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at Thr-451 and Thr-461 and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution. Tsai L.-H., Nature 371:419-423(1994). Patrick G.N., Nature 402:615-622(1999). Kesavapany S., J. Neurosci. 24:4421-4431(2004).

Human, Mouse, Rat

-20°C or -80°C

41116161