Bio-Connect
GTX135120 WB Image
GTX135120 WB Image
GTX135120 WB Image

CDKN2A / p16INK4a antibody

Research Use Only
GTX135120
GeneTex
Product group Antibodies
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    GeneTex
  • Product Name
    CDKN2A / p16INK4a antibody
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    0.9 mg/ml
  • Isotype
    IgG
  • Scientific Description
    This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203