CEA Antibody / Carcinoembryonic Antigen

Biorbyt

CEA Antibody / Carcinoembryonic Antigen

10

Optimal dilution of the CEA antibody to be determined by the researcher.1. Staining of formalin-fixed tissues requires boiling tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min followed by cooling at RT for 20 min

ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Immunohistochemistry (FFPE): 0.25-0.5ug/ml for 30 min at RT (1) (2) IHC-P

Research Use Only

Monoclonal

C66/195

Unconjugated

CEACAM5

CEA cell adhesion molecule 5

CD66e, CEA, cell adhesion molecule CEACAM5, carcinoembryonic antigen related cell adhesion molecule 5, meconium antigen 100

Mouse

IgG1

Cell adhesion molecule CEACAM5

This antibody recognizes proteins of 80-200kDa, identified as different members of CEA family. CEA is synthesized during development in the fetal gut and is re-expressed in increased amounts in intestinal carcinomas and several other tumors. This mAb reacts with nonspecific cross-reacting antigen (NCA) and shows a cross-reaction with human polymorphonuclear leucocytes. It shows no reaction with a variety of normal tissues and is suitable for staining of formalin/paraffin tissues. CEA is not found in benign glands, stroma, or malignant prostatic cells. Antibody to CEA is useful in detecting early foci of gastric carcinoma and in distinguishing pulmonary adenocarcinomas (60-70% are CEA+) from pleural mesotheliomas (rarely or weakly CEA+). Anti-CEA positivity is seen in adenocarcinomas from the lung, colon, stomach, esophagus, pancreas, gallbadder, urachus, salivary gland, ovary, and endocervix.

-20°C,2°C to 8°C

12352203