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CENP-A Antibody (OASE00147)

OASE00147
Aviva Systems Biology
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Product group Antibodies
TargetCENPA
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Overview

  • Supplier
    Aviva Systems Biology
  • Product Name
    CENP-A Antibody (OASE00147)
  • Delivery Days Customer
    23
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    5A7-2E11
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID1058
  • Target name
    CENPA
  • Target description
    centromere protein A
  • Target synonyms
    CENP-A, CenH3, histone H3-like centromeric protein A, centromere autoantigen A, centromere protein A, 17kDa, centromere-specific histone
  • Host
    Mouse
  • Isotype
    IgG1
  • Scientific Description
    A replicated chromosome includes two kinetochores that control chromosome segregation during mitosis. The Centromere Protein-A, CENP-A, is a Histone H3-like protein that contains a C-terminal H3-like domain, which is required for centromere localization of CENP-A, and an antigenic N-terminal domain. CENP-A, originally isolated from HeLa cells, is essential for kinetochore targeting of CENP-C. In the presence of DNA CENP-A forms an octa-meric complex with histones H4, H2A, H2B. CENP-A specifically localizes to active centromeres and is a component of specialized centromeric nucleosomes, on which kinetochores are assembled. CENP-A is essential for nucleosomal packaging of centromeric DNA at interphase and functions as a centromere formation marker on the chromosome.
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203