Immunohistochemical detection of CENP-A on paraffin embedded section of a squamous epithelium of human tonsil.
Immunohistochemical detection of CENP-A on paraffin embedded section of a squamous epithelium of human tonsil.
CENPA antibody [3-19]
GTX13939
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Neutralisation/Blocking
Product group Antibodies
ReactivityC. Elegans, Chicken, Human
TargetCENPA
Overview
- SupplierGeneTex
- Product NameCENPA antibody [3-19]
- Delivery Days Customer9
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Neutralisation/Blocking
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID3-19
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID1058
- Target nameCENPA
- Target descriptioncentromere protein A
- Target synonymsCenH3; CENP-A; centromere autoantigen A; centromere protein A, 17kDa; centromere-specific histone; histone H3-like centromeric protein A
- HostMouse
- IsotypeIgG1
- Scientific DescriptionCentromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015]
- ReactivityC. Elegans, Chicken, Human
- Storage Instruction2°C to 8°C,-20°C or -80°C
- UNSPSC12352203
References
- Structure of the human inner kinetochore CCAN complex and its significance for human centromere organization. Pesenti ME et al., 2022 Jun 2, Mol CellRead more
- Chromosome length and gene density contribute to micronuclear membrane stability. Mammel AE et al., 2022 Feb, Life Sci AllianceRead more
- CRISPR/Cas9 screening identifies a kinetochore-microtubule dependent mechanism for Aurora-A inhibitor resistance in breast cancer. Chen A et al., 2021 Feb, Cancer Commun (Lond)Read more
- Reconstitution of a 26-Subunit Human Kinetochore Reveals Cooperative Microtubule Binding by CENP-OPQUR and NDC80. Pesenti ME et al., 2018 Sep 20, Mol CellRead more
- Chmp4c is required for stable kinetochore-microtubule attachments. Petsalaki E et al., 2018 Dec, ChromosomaRead more
- hDNA2 nuclease/helicase promotes centromeric DNA replication and genome stability. Li Z et al., 2018 Jul 13, EMBO JRead more
- The ESCRT protein Chmp4c regulates mitotic spindle checkpoint signaling. Petsalaki E et al., 2018 Mar 5, J Cell BiolRead more
- Decoding the centromeric nucleosome through CENP-N. Pentakota S et al., 2017 Dec 27, ElifeRead more
- Insights from biochemical reconstitution into the architecture of human kinetochores. Weir JR et al., 2016 Sep 8, NatureRead more
- Clks 1, 2 and 4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint. Petsalaki E et al., 2016 Apr 29, Nat CommunRead more