CEP-32496 hydrochloride

Biorbyt

CEP-32496 hydrochloride [1227678-26-3]

16

1227678-26-3

Research Use Only

C24H23ClF3N5O5

553.92

CEP-32496 Hcl is a highly potent inhibitor of BRAF(V600E/WT) and c-Raf with Kd of 14 nM/36 nM and 39 nM, also potent to Abl-1, c-Kit, Ret, PDGFRbeta and VEGFR2, respectively; insignificant affinity for MEK-1, MEK-2, ERK-1 and ERK-2.

O=C(NC1C=C(OC2N=CN=C3C=C(OC)C(OC)=CC=23)C=CC=1)NC1C=C(C(C(F)(F)F)(C)C)ON=1.[H]Cl

12352200