Ceralasertib formate [1352280-98-8]

TargetMol Chemicals

Ceralasertib formate [1352280-98-8]

72

1352280-98-8

Research Use Only

Ceralasertib formate

C21H26N6O4S

458.54

Ceralasertib is an orally available inhibitor of ataxia telangiectasia and rad3 related (ATR) kinase. Ceralasertib selectively inhibits ATR activity by blocking the downstream phosphorylation of the serine/threonine protein kinase CHK1. This prevents ATR-mediated signaling, and results in the inhibition of DNA damage checkpoint activation, disruption of DNA damage repair, and the induction of tumor cell apoptosis.

3 years

OC=O.C[C@@H]1COCCN1c1cc(nc(n1)-c1ccnc2[nH]ccc12)C1(CC1)[S@](C)(=N)=O

-20°C

12352200