CERS4 Polyclonal Antibody

Reddot Biotech

CERS4 Polyclonal Antibody

5

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

0.9 mg/ml

Unconjugated

CERS4

ceramide synthase 4

ceramide synthase 4; LAG1 homolog, ceramide synthase 4; LAG1 longevity assurance homolog 4; LASS4; sphingosine N-acyltransferase CERS4; Trh1

Rabbit

IgG

The LASS (longevity assurance homolog) family members are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1, LASS2, LASS3, LASS4, LASS5 and LASS6) and they are all involved in sphingolipid synthesis. LASS4 is a 394 amino acid endoplasmic reticulum, multi-pass membrane protein. LASS4 increases the levels of long ceramides such as C22:0- and C24:0-ceramides. In cells deficient for CLN9, as observed in neuronal ceroid lipofuscinosis (NCL) or Batten disease, LASS4 can increase ceramide levels and partially correct growth and apoptosis.

Human

-20°C

12352203