cGAMP . 2Na [STING Ligand] [849214-04-6]

AdipoGen Life Sciences

cGAMP . 2Na [STING Ligand]

10

849214-04-6

Research Use Only

>98%

C20H24N10O13P2 . 2Na

674.4 . 46.0

Chemical. CAS: 849214-04-6 (free acid). Formula: C20H24N10O13P2 . 2Na. MW: 674.4 . 46.0. Synthetic. Potent STING ligand. Second messenger in human and mouse cells that triggers interferon production in response to cytosolic DNA. Binding to STING leads to activation of IRF3 (IFN regulatory factor 3) and the induction of interferon-beta. First cyclic nucleotide in metazoa. Plays a role in bacterial chemotaxis and colonization. - Potent STING ligand [2-8]. Second messenger in human and mouse cells that triggers interferon production in response to cytosolic DNA [2-4]. Binding to STING leads to activation of IRF3 (IFN regulatory factor 3) and the induction of interferon-beta [3-6]. First cyclic nucleotide in metazoa [4]. Plays a role in bacterial chemotaxis and colonization [1].

[Na+].[Na+].NC1=NC2=C(N=CN2C2O[C@H]3CO[P@@]([O-])(=O)OC4C(COP([O-])(=O)OC3C2O)O[C@@H](C4O)N2C=NC3=C(N)N=CN=C23)C(=O)N1

-20°C,2°C to 8°C

12352200