CGP52411 [145915-58-8]

MedChem Express

CGP52411 [145915-58-8]

10

145915-58-8

Research Use Only

99.82

C20H15N3O2

329.35

CGP52411 (DAPH) is a high selective, potent, orally active and ATP-competitive EGFR inhibitor with an IC50 of 0.3 microM. CGP52411 blocks the toxic influx of Ca2+ ions into neuronal cells, and dramatic inhibits and reverses the formation of beta-amyloid (Abeta42) fibril aggregates associated with Alzheimers disease[1][2].

O=C1NC(C2=C1C=C(NC3=CC=CC=C3)C(NC4=CC=CC=C4)=C2)=O

-20°C,2°C to 8°C

12352200