CHCHD2 antibody

GeneTex

CHCHD2 antibody

9

Flow Cytometry, Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

Unconjugated

CHCHD2

coiled-coil-helix-coiled-coil-helix domain containing 2

16.7kD protein; aging-associated gene 10 protein; C7orf17; coiled-coil-helix-coiled-coil-helix domain-containing protein 2; coiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrial; HCV NS2 trans-regulated protein; mitochondria nuclear retrograde regulator 1; mitochondrial nuclear retrograde regulator 1; MIX17 homolog B; MIX17B; MNRR1; NS2TP; PARK22

Rabbit

IgG

Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

The protein encoded by this gene belongs to a class of eukaryotic CX(9)C proteins characterized by four cysteine residues spaced ten amino acids apart from one another. These residues form disulfide linkages that define a CHCH fold. In response to stress, the protein translocates from the mitochondrial intermembrane space to the nucleus where it binds to a highly conserved 13 nucleotide oxygen responsive element in the promoter of cytochrome oxidase 4I2, a subunit of the terminal enzyme of the electron transport chain. In concert with recombination signal sequence-binding protein J, binding of this protein activates the oxygen responsive element at four percent oxygen. In addition, it has been shown that this protein is a negative regulator of mitochondria-mediated apoptosis. In response to apoptotic stimuli, mitochondrial levels of this protein decrease, allowing BCL2-associated X protein to oligomerize and activate the caspase cascade. Pseudogenes of this gene are found on multiple chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Human

-20°C or -80°C,2°C to 8°C

12352203