A 83-01

MedChem Express

A 83-01 [909910-43-6]

10

909910-43-6

Research Use Only

99.41

C25H19N5S

421.52

A 83-01 is a potent inhibitor of TGF-beta type I receptor ALK5 kinase , type I nodal receptor ALK4 and type I nodal receptor ALK7 , with IC 50 s of 12 nM, 45 nM and 7.5 nM against the transcription induced by ALK5 , ALK4 and ALK7 , respectively [1] .

S=C(N1N=C(C2=NC(C)=CC=C2)C(C3=CC=NC4=CC=CC=C34)=C1)NC5=CC=CC=C5

-20°C

12352200