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Gefitinib-based PROTAC 3 [2230821-27-7]

HY-123921
MedChem Express
CAS Number2230821-27-7
Product group Chemicals
Estimated Purity98.01%
Molecular Weight934.51
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Packing Size
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Gefitinib-based PROTAC 3 [2230821-27-7]
  • Delivery Days Customer
    10
  • CAS Number
    2230821-27-7
  • Estimated Purity
    98.01%
  • Molecular Formula
    C47H57ClFN7O8S
  • Molecular Weight
    934.51
  • Scientific Description
    Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a von Hippel-Lindau ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively.
  • SMILES
    O=C([C@H]1N(C([C@@H](NC(CCOCCOCCCCCOC2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N=CN=C3C=C2OC)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5
  • Storage Instruction
    2°C to 8°C,-20°C,-80°C
  • UNSPSC
    12352200