Gefitinib-based PROTAC 3 [2230821-27-7]
T5437
CAS Number2230821-27-7
Product group Chemicals
Molecular Weight934.51
Overview
- SupplierTargetMol Chemicals
- Product NameGefitinib-based PROTAC 3
- Delivery Days Customer9
- CAS Number2230821-27-7
- Category SupplierChemical
- CertificationResearch Use Only
- Chemical NameGefitinib-based PROTAC 3
- Molecular FormulaC47H57ClFN7O8S
- Molecular Weight934.51
- Scientific DescriptionGefitinib-based PROTAC 3, which connects an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827 (exon 19 del) and H3255 (L858R mutation) cells, respectively[1].
- Shelf life instruction3 years
- SMILESN(C=1C2=C(C=C(OC)C(OCCCCCOCCOCCC(N[C@H](C(=O)N3[C@H](C(NCC4=CC=C(C=C4)C=5SC=NC5C)=O)C[C@@H](O)C3)[C@](C)(C)C)=O)=C2)N=CN1)C6=CC(Cl)=C(F)C=C6
- Storage Instruction-20°C
- UNSPSC12352200
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