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ProductsBack/LY294002 [154447-36-6]

LY294002 [154447-36-6]

Research Use Only

S1105

CAS Number154447-36-6

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Product group Chemicals

Overview

Supplier
Selleck Chemicals
Product Name
LY294002 [154447-36-6]
Delivery Days Customer
9
CAS Number
154447-36-6
Certification
Research Use Only
Scientific Description
LY294002 (SF 1101, NSC 697286) is the first synthetic molecule known to inhibit PI3Kalfa/delta/bèta with IC50 of 0.5 muM/0.57 muM/0.97 muM, respectively; more stable in solution than Wortmannin, and also blocks autophagosome formation. It not only binds to class I PI3Ks and other PI3K-related kinases, but also to novel targets seemingly unrelated to the PI3K family. LY294002 also inhibits CK2 with IC50 of 98 nM. LY294002 is a non-specific DNA-PKcs inhibitor and activates autophagy and apoptosis.
UNSPSC
12352200