CHFR antibody

GeneTex

CHFR antibody

9

ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, ImmunoCytoChemistry

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

CHFR

checkpoint with forkhead and ring finger domains

checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase CHFR; RING finger protein 196; RING-type E3 ubiquitin transferase CHFR; RNF116; RNF196

Rabbit

IgG

E3 ubiquitin-protein ligase CHFR

E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the Lys-48-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of Lys-63-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at Lys-63 are usually not targeted for degradation, but are rather involved in signaling cellular stress.

Human

-20°C or -80°C,2°C to 8°C

12352203