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Chidamide [743420-02-2]

Chidamide [743420-02-2]

Research Use Only
27202
BPS Bioscience
CAS Number743420-02-2
Product group Chemicals
Estimated Purity≥98%
Molecular Weight390.4 Da
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Overview

  • Supplier
    BPS Bioscience
  • Product Name
    Chidamide
  • Delivery Days Customer
    7
  • CAS Number
    743420-02-2
  • Certification
    Research Use Only
  • Estimated Purity
    ≥98%
  • Molecular Formula
    C22H19FN4O2
  • Molecular Weight
    390.4 Da
  • Scientific Description
    Chidamide is a histone deacetylase inhibitor which increases Histone H3 acetylation levels in LoVo and HT29 colon cancer cells at low concentrations (4 microM). Chidamide affects the activation of oncogenic signaling kinases by dose-dependently reducing phosphorylated Akt, mTOR, p70S6K, Raf and Erk 1/2 protein expression in colon cancer cells. Chidamide also dose-dependently upregulates p21 protein expression, down-regulates CDK4, and induces cell cycle arrest at the G0/G1 phase.
  • Storage Instruction
    -20°C
  • UNSPSC
    51202000