CHIR-98014

MedChem Express

CHIR-98014 [252935-94-7]

10

252935-94-7

Research Use Only

98.0

C20H17Cl2N9O2

486.31

CHIR-98014 is a potent, cell-permeable GSK-3 inhibitor with IC 50 s of 0.65 and 0.58 nM for GSK-3alpha and GSK-3beta , respectively; it shows less potent activities against cdc2 and erk2.

ClC1=CC(Cl)=CC=C1C2=NC(NCCNC3=CC=C([N+]([O-])=O)C(N)=N3)=NC=C2N4C=CN=C4

-20°C,2°C to 8°C

12352200