CHIR-99021 HCl
T2310L
CAS Number1797989-42-4
Product group Chemicals
Molecular Weight501.8
Overview
- SupplierTargetMol Chemicals
- Product NameCHIR-99021 HCl
- Delivery Days Customer4
- CAS Number1797989-42-4
- Category SupplierChemical
- Chemical NameCHIR-99021 HCl
- Molecular FormulaC22H19Cl3N8
- Molecular Weight501.8
- Scientific DescriptionCHIR-99021 HCl (Laduviglusib HCl) is a highly potent and selective inhibitor of GSK-3alfa/bèta, with IC50 values of 10 nM and 6.7 nM respectively. It demonstrates remarkable selectivity for GSK-3, with over 500-fold selectivity over CDC2, ERK2, and other protein kinases. Additionally, CHIR-99021 HCl serves as a robust activator of the Wnt/bèta-catenin signaling pathway. Moreover, it exhibits the ability to enhance self-renewal in both mouse and human embryonic stem cells. Furthermore, CHIR-99021 HCl induces autophagy [1] [2] [3].
- Shelf life instruction3 years
- SMILESCl.N#CC1=CN=C(C=C1)NCCNC=2N=CC(C3=NC=C(N3)C)=C(N2)C=4C=CC(Cl)=CC4Cl
- Storage Instruction-20°
- UNSPSC12352200
References
- Ye S, et al. Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embryonic stem cells from refractory mouse strains. PLoS One. 2012;7(4):e35892.