The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA800200(CHRDL2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200)
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA800200(CHRDL2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200)
CHRDL2 Antibody
CSB-PA800200
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetCHRDL2
Overview
- SupplierCusabio
- Product NameCHRDL2 Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID25884
- Target nameCHRDL2
- Target descriptionchordin like 2
- Target synonymsBNF1, CHL2, chordin-like protein 2, breast tumor novel factor 1, chordin-related protein 2
- HostRabbit
- IsotypeIgG
- Protein IDQ6WN34
- Protein NameChordin-like protein 2
- Scientific DescriptionCHRDL2 (chordin-related protein 2), also known as BNF1 (breast tumor novel factor 1) or CHL2 (chordin-like 2), is a 429 amino acid protein that belongs to the chordin family of proteins. CHRDL2 contains three VWFC (von Willebrand Factor type C) domains and is predominantly expressed in uterus and moderately expressed in prostate, liver, ovary, heart and testis. Due to alternative splicing events, CHRDL2 exists as five isoforms, namely isoform I, isoform II, isoform VII, isoform VIII and isoform IX. Two of these isoforms are secreted, while the other three localize to the cytoplasm. Functioning as a BMP-binding inhibitor, CHRDL2 directly interacts with BMPs and blocks their binding to BMP receptors, thereby inhibiting BMP activity. In breast, lung and colon tumors, CHRDL2 expression is upregulated, suggesting a possible role in tumorigenesis.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC41116161
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