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Chromogranin C antibody

Name: Chromogranin C antibody
SKU: GTX116446_G10
Availability: BackOrder

GTX116446

ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

ReactivityHuman, Mouse

TargetSCG2

Overview

Supplier
GeneTex
Product Name
Chromogranin C antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Concentration
0.26 mg/ml
Conjugate
Unconjugated
Gene ID7857
Target name
SCG2
Target description
secretogranin II
Target synonyms
CHGC, EM66, SN, SgII, secretogranin-2, chromogranin-C, secretoneurin
Host
Rabbit
Isotype
IgG
Protein IDP13521
Protein Name
Secretogranin-2
Scientific Description
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. [provided by RefSeq]
Reactivity
Human, Mouse
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Lin Z, Li Y, Hang Y, et al. Tuning the Size of Large Dense-Core Vesicles and Quantal Neurotransmitter Release via Secretogranin II Liquid-Liquid Phase Separation. Adv Sci (Weinh). 2022,9(27):e2202263. doi: 10.1002/advs.202202263
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Xiang H, Chen S, Zhou J, et al. Characterization of blood-derived exosomal proteins after exercise. J Int Med Res. 2020,48(9):300060520957541. doi: 10.1177/0300060520957541
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Moro A, van Woerden GM, Toonen RF, et al. CaMKII controls neuromodulation via neuropeptide gene expression and axonal targeting of neuropeptide vesicles. PLoS Biol. 2020,18(8):e3000826. doi: 10.1371/journal.pbio.3000826
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Federico A, Steinfass T, Larribère L, et al. Mithramycin A and Mithralog EC-8042 Inhibit SETDB1 Expression and Its Oncogenic Activity in Malignant Melanoma. Mol Ther Oncolytics. 2020,18:83-99. doi: 10.1016/j.omto.2020.06.001
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Valiya Veettil M, Krishna G, Roy A, et al. Kaposi's Sarcoma-Associated Herpesvirus Infection Induces the Expression of Neuroendocrine Genes in Endothelial Cells. J Virol. 2020,94(8). doi: 10.1128/JVI.01692-19
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Peitsch WK, Doerflinger Y, Fischer-Colbrie R, et al. Desmoglein 2 depletion leads to increased migration and upregulation of the chemoattractant secretoneurin in melanoma cells. PLoS One. 2014,9(2):e89491. doi: 10.1371/journal.pone.0089491
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