CI-898 HCl [1658520-97-8]
T70304
Molecular Weight478.8
Product group Chemicals
Overview
- SupplierTargetMol Chemicals
- Product NameCI-898 HCl [1658520-97-8]
- Delivery Days Customer72
- CertificationResearch Use Only
- Chemical NameCI-898 HCl
- Molecular FormulaC19H26Cl3N5O3
- Molecular Weight478.8
- Scientific DescriptionCI-898 HCl is a lipophilic antifolate inhibitor of dihydrofolate reductase (DHFR). It has enhanced binding to DHFR in the presence of the cofactor NADPH. Cl-898 HCl inhibits cell growth and halts the cell cycle at the G1/S phase in L1210 mouse lymphocytic leukemia cells and is active against methotrexate-resistant cancer cell lines. It also enhances the activity of doxorubicin, cyclophosphamide, and 6-thioguanine (6-TG) in mice with advanced stage P338 leukemia.
- Shelf life instruction3 years
- SMILESCl.Cl.Cl.COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC
- Storage Instruction-20°C
- UNSPSC12352200