CIB-L43

MedChem Express

CIB-L43

5

Research Use Only

99.71

C15H16N2O3S

304.36

CIB-L43 is an orally active TRBP inhibitor (KD = 4.78 nM) and enhances disruption of TRBP-Dicer interactions (IC50 = 2.34 microM). CIB-L43 suppresses oncogenic miR-21 biosynthesis, increasing PTEN and Smad7 expression and inhibiting AKT and TGF-beta signaling, thereby reducing HCC cell proliferation and migration[1].

OC(C1=C(N=C(C2=CC=C(C=C2)N3CCOCC3)S1)C)=O

-20°C,2°C to 8°C

12352200