Cilazaprilat [90139-06-3]

MedChem Express

Cilazaprilat [90139-06-3]

5

90139-06-3

Research Use Only

C20H27N3O5

389.45

Cilazaprilat is an inhibitor of angiotensin-converting enzyme (ACE; IC50=0.7 nM for the rat enzyme) and an active metabolite of Cilazapril (HY-A0043). It decreases creatine kinase release in primary neonatal rat cardiac myocytes in an in vitro model of ischemia-reperfusion injury induced by hypoxia and reoxygenation when used at a concentration of 10 microM.3 Intra-arterial administration of cilazaprilat (3 microg/kg per minute) increases coronary blood flow and fractional shortening in a dog model of coronary hypoperfusion-induced myocardial ischemia.

O=C([C@@H]1CCCN2N1C([C@@H](N[C@H](C(O)=O)CCC3=CC=CC=C3)CCC2)=O)O

12352200