Cilengitide

MedChem Express

Cilengitide [188968-51-6]

10

188968-51-6

Research Use Only

99.80

C27H40N8O7

588.66

Cilengitide (EMD 121974) is a potent integrins antagonist with IC 50 s of 0.61 nM ( alpha nu beta 3 ), 8.4 nM ( alpha nu beta 5 ) and 14.9 nM ( alpha 5 beta 1 ), respectively. Cilengitide inhibits the binding of alpha nu beta 3 and alpha nu beta 5 to Vitronectin with IC 50 s of 4 nM and 79 nM, respectively. Cilengitide inhibits TGF-beta/Smad signaling, mediates PD-L1 expression. Cilengitide also induces apoptosis , shows antiangiogenic effect in the research against glioblastoma and other cancers [1] [2] [3] .

O=C(NCC(N[C@H](C(N[C@H](CC1=CC=CC=C1)C(N([C@H]2C(C)C)C)=O)=O)CC(O)=O)=O)[C@H](CCCNC(N)=N)NC2=O

-20°C

12352200