Cilomilast

MedChem Express

Cilomilast [153259-65-5]

10

153259-65-5

Research Use Only

99.91

C20H25NO4

343.42

Cilomilast (SB-207499) is a potent, selective and orally active inhibitor of Phosphodiesterase 4 (PDE4) , with IC 50 s of ~100 and 120 nM for LPDE4 and HPDE4, respectively. Cilomilast shows selectivity for PDE4 over PDE1, PDE2, PDE3 and PDE5 ( IC 50 =74, 65, >100, and 83 microM, respectively). Cilomilast has anti-inflammatory and immunomodulatory effects and can be used for thr research of asthma and chronic obstructive pulmonary disease (COPD) [1] [2] [3] .

O=C([C@H]1CC[C@@](C#N)(CC1)C2=CC=C(OC)C(OC3CCCC3)=C2)O

-20°C,2°C to 8°C

12352200