cis-4-Br-2,5-F2-PCPA

MedChem Express

cis-4-Br-2,5-F2-PCPA [2821068-03-3]

10

Research Use Only

C9H8BrF2N

248.07

cis-4-Br-2,5-F2-PCPA (S1024) is a selective inhibitor of lysine-specific demethylase 1 (LSD1), with a Ki value of 94 nM instead of 8.4 microM for LSD2. There is aberrant expression of LSD1 in cancer stem cells, cis-4-Br-2,5-F2-PCPA inhibits LSD1 cell proliferation and by increasing the level of dimethylated histone H3 at K4 (H3K4) in CCRF-CEM cells[1].

N[C@@H]1C[C@@H]1C2=C(F)C=C(Br)C(F)=C2

12131703