cis-INCB3344 [1285539-85-6]

MedChem Express

cis-INCB3344 [1285539-85-6]

14

1285539-85-6

Research Use Only

95.10

C29H34F3N3O6

577.59

cis-INCB3344 is the isomer of INCB3344 (HY-50674), and can be used as an experimental control. INCB3344 is a potent, selective and orally bioavailable CCR2 antagonist with IC50 values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM (mCCR2) in antagonism of chemotaxis activity.

O=C(NCC(N[C@H]1CN([C@@H]2CC[C@](C3=CC=C(OCO4)C4=C3)(O)CC2)C[C@@H]1OCC)=O)C5=CC=CC(C(F)(F)F)=C5

-20°C,2°C to 8°C

12352200