cis-MZ 1 (hydrate)

MedChem Express

cis-MZ 1 (hydrate)

5

Research Use Only

99.0

C49H60ClN9O8S2.1/4H2O

1007.15

cis-MZ 1 hydrate is a negative control for BRD4 -targeted PROTAC MZ 1 (HY-107425). cis-MZ 1 or MZ 1 is a combination of the von Hippel-Lindau ligand (red part in the structural formula) and the BRD4 ligand (blue part in the structural formula). The K d of MZ 1 for BRD4 BD1/2 was 382 nM and 120 nM, respectively [1] .

CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@@H](CC(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@@H](C4)O)C(NCC5=CC=C(C6=C(N=CS6)C)C=C5)=O)=O)=O)=O)C7=NN=C(C)N27.[0.25].O

-20°C

12352200