cis-Resveratrol [61434-67-1]

TargetMol Chemicals

cis-Resveratrol [61434-67-1]

14

61434-67-1

Research Use Only

cis-Resveratrol

C14H12O3

228.247

Resveratrol is a potent phenolic antioxidant found in grapes, red wine, and various berries that also has antiproliferative and anti-inflammatory activity. cis-Resveratrol is the double bond isomer of trans-resveratrol, the more often studied and naturally abundant of the two resveratrol isomers. cis-Resveratrol exhibits antioxidant activity in the &#181M range similar to that observed with trans-resveratrol. It blocks production of reactive oxygen species (ROS) by inhibition of NAD(P)H oxidase and also inhibits production of nitric oxide. At a concentration of 100 &#181M, cis-resveratrol significantly inhibits the expression of genes related to the Rel/NF-kappaB/IkappaB family, adhesion molecules, and acute-phase proteins in LPS and INF-gamma-stimulated murine peritoneal macrophages. cis-Resveratrol inhibits uptake of noradrenaline and 5-HT by synaptosomes from rat brain with IC50 values of 79 and 51 &#181M, respectively. It also inhibits human monoamine oxidase-A (MOA-A) and MOA-B with IC50 values of 25 and 61 &#181M, respectively, which is similar to, but slightly less effective than, values obtained with trans-resveratrol.

3 years

Oc1ccc(\C=C/c2cc(O)cc(O)c2)cc1

-20°C

12352200