cis-VZ185 [2306193-98-4]

MedChem Express

cis-VZ185 [2306193-98-4]

9

2306193-98-4

Research Use Only

C53H67FN8O8S

995.21

cis-VZ185 is a VHL-based PROTACs degrader with the activity of degrading BRD9 and BRD7. cis-VZ185 can be optimized from suboptimal compounds by optimizing the connection mode and linker, and has efficient, rapid and selective degradation of BRD9 and its homologous protein BRD7.

CN1C=C(C2=CC=NC=C2C1=O)C3=CC(OC)=C(CN4CCN(CCCCCOC5=C(CNC([C@H]6N(C([C@@H](NC(C7(F)CC7)=O)C(C)(C)C)=O)C[C@@H](O)C6)=O)C=CC(C8=C(N=CS8)C)=C5)CC4)C(OC)=C3

12352200