CJ-15208 [210236-47-8]

MedChem Express

CJ-15208 [210236-47-8]

9

210236-47-8

Research Use Only

C34H35N5O4

577.67

CJ-15208 is a potent and selective kappa-opioid receptor antagonist with significant opioid activity. CJ-15208 exhibited strong analgesic effects in the warm water tail withdrawal test in mice and was mediated through multiple opioid receptors. The stereoisomers of CJ-15208 exhibited different opioid activity characteristics, for example, one stereoisomer exhibited kappa-opioid receptor antagonism, while the other exhibited delta-opioid receptor antagonism. All stereoisomers of CJ-15208 had no significant effects on respiration. The stereoisomers of CJ-15208 did not lead to the development of drug tolerance, which makes it potential in the further development of safe opioid analgesics[1].

O=C(N[C@H](C(N1[C@@](CCC1)([H])C(N[C@H](C(N2)=O)CC3=CC=CC=C3)=O)=O)CC4=CC=CC=C4)[C@@H]2CC5=CNC6=CC=CC=C56

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