CL2-SN-38(DCA)

Biorbyt

CL2-SN-38(DCA)

10

1036969-20-6

Research Use Only

C82H106N12O23

1627.79

CL2-SN-38 is a cleavable linker-based antibody-drug conjugate (ADC) containing the topoisomerase I inhibitor SN-38 (Item No. 15632) and a maleimidocaproyl linker.1 CL2-SN-38 has been linked to tumor-selective human monoclonal antibodies, such as anti-CEACAM5 (hMN-14) to target SN-38 to tumor sites and improve its solubility. CL2-SN-38 linked to hMN-14 binds (Kd = 1.4 nM) and is cytotoxic to LoVo human colon adenocarcinoma cells (IC50 = 5.3 nM). CL2-SN-38 linked to hMN-14 increases survival in a colon carcinoma mouse model of lung metastasis.

O=C1N(CC2=C3CC)C(C2=NC4=CC=C(O)C=C34)=CC([C@@](CC)5OC(OCC6=CC=C(NC([C@H](CCCCN)NC([C@@H](NC(COCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCN7C=C(CNC(C8CCC(CN(C9=O)C(C=C9)=O)CC8)=O)N=N7)=O)=O)CC%10=CC=CC=C%10)=O)=O)C=C6)=O)=C1COC5=O

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