Claudin 8 antibody, C-term
GTX77832
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetCLDN8
Overview
- SupplierGeneTex
- Product NameClaudin 8 antibody, C-term
- Delivery Days Customer9
- Application Supplier NoteWB: 0.2-2.5 ug/ml. IHC-P: 2-10 ug/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.5-1 mg/ml
- ConjugateUnconjugated
- Gene ID9073
- Target nameCLDN8
- Target descriptionclaudin 8
- Target synonymsHEL-S-79, claudin-8, epididymis secretory protein Li 79
- HostRabbit
- IsotypeIgG
- Protein IDP56748
- Protein NameClaudin-8
- Scientific DescriptionThis gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.[provided by RefSeq, May 2010]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Zhuang X, Chen B, Huang S, et al. Hypermethylation of miR-145 promoter-mediated SOX9-CLDN8 pathway regulates intestinal mucosal barrier in Crohn's disease. EBioMedicine. 2022,76:103846. doi: 10.1016/j.ebiom.2022.103846Read this paper
- Liu C, Tate T, Batourina E, et al. Pparg promotes differentiation and regulates mitochondrial gene expression in bladder epithelial cells. Nat Commun. 2019,10(1):4589. doi: 10.1038/s41467-019-12332-0Read this paper
- Wang H, Chao K, Ng SC, et al. Pro-inflammatory miR-223 mediates the cross-talk between the IL23 pathway and the intestinal barrier in inflammatory bowel disease. Genome Biol. 2016,17:58. doi: 10.1186/s13059-016-0901-8Read this paper
- Petersson F, Síma R, Grossmann P, et al. Renal small cell oncocytoma with pseudorosettes A histomorphologic, immunohistochemical, and molecular genetic study of 10 cases. Hum Pathol. 2011,42(11):1751-60. doi: 10.1016/j.humpath.2011.01.022Read this paper
- Lechpammer M, Resnick MB, Sabo E, et al. The diagnostic and prognostic utility of claudin expression in renal cell neoplasms. Mod Pathol. 2008,21(11):1320-9. doi: 10.1038/modpathol.2008.116Read this paper
- Dubé E, Hermo L, Chan PT, et al. Alterations in gene expression in the caput epididymides of nonobstructive azoospermic men. Biol Reprod. 2008,78(2):342-51.Read this paper
- Hermo L, Korah N, Gregory M, et al. Structural alterations of epididymal epithelial cells in cathepsin A-deficient mice affect the blood-epididymal barrier and lead to altered sperm motility. J Androl. 2007,28(5):784-97.Read this paper
- Dubé E, Chan PT, Hermo L, et al. Gene expression profiling and its relevance to the blood-epididymal barrier in the human epididymis. Biol Reprod. 2007,76(6):1034-44.Read this paper
- Rohan S, Tu JJ, Kao J, et al. Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes. Clin Cancer Res. 2006,12(23):6937-45.Read this paper
Datasheet
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