Clozapine

MedChem Express

Clozapine [5786-21-0]

5

5786-21-0

Research Use Only

99.84

C18H19ClN4

326.831

Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a K i of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with K i s of 9.5 nM and 4 nM, respectively [1] [2] [3] . Clozapine is also a potent and selective agonist at the muscarinic M4 receptor ( EC 50 =11 nM) [4] .

CN1CCN(CC1)C2=NC3=CC(Cl)=CC=C3NC4=CC=CC=C42

-20°C,2°C to 8°C

12352200