Clozapine N-oxide [34233-69-7]

MedChem Express

Clozapine N-oxide [34233-69-7]

10

34233-69-7

Research Use Only

99.98

C18H19ClN4O

342.82

Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide can cross the blood-brain barrier[1][2][3][4]. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist[5][6].

[O-][N+]1(C)CCN(C2=NC3=CC(Cl)=CC=C3NC4=CC=CC=C42)CC1

-20°C,2°C to 8°C

12352200