CM-272

MedChem Express

CM-272 [1846570-31-7]

9

1846570-31-7

98.70

C28H38N4O3

478.63

CM-272 is a first-in-class, potent, selective, substrate-competitive and reversible dual G9a/DNA methyltransferases (DNMTs) inhibitor with antitumor activities. CM-272 inhibits G9a , DNMT1 , DNMT3A , DNMT3B and GLP with IC 50 s of 8 nM, 382 nM, 85 nM, 1200 nM and 2 nM, respectively. CM-272 inhibits cell proliferation and promotes apoptosis , inducing IFN-stimulated genes and immunogenic cell death [1] .

CN(CC1)CCC1NC2=CC(C3=CC=C(C)O3)=NC4=CC(OCCCN5CCCC5)=C(OC)C=C42

-20°C,2°C to 8°C

12352200