CM398

Biorbyt

CM398 [1121931-70-1]

10

1121931-70-1

Research Use Only

C23H29N3O3

395.49

CM398 is a highly selective, orally active sigma-2 receptor ligand (Ki=0.43 nM), with high sigma-1/sigma-2 selectivity rato (1000-fold). CM398 shows notable affinity for dopamine (Ki=32.90 nM) and serotonin transporters (Ki=244.2 nM). CM398 shows promising anti-inflammatory analgesic effects in the formalin model of inflammatory pain in mice.

C1CC2C(=CC(OC)=C(C=2)OC)CN1CCCCN1C(=O)N(C)C2C1=CC=CC=2

12352200