CMV pp65 (residues 297-510), Cytomegalo Virus Phosphoprotein 65, recombinant, E. coli

Jena Bioscience

CMV pp65 (residues 297-510), Cytomegalo Virus Phosphoprotein 65, recombinant, E. coli

5

Western Blot, ELISA

Research Use Only

>95%

The protein contains the CMV pp65 immunodominant regions, amino acids 297-510. It is fused to a 26 kDa GST-tag. The protein is purified by proprietary chromatographic technique. Background: The E. coli derived protein contains the CMV Pp65 immunodominant regions, 297-510 aa. It is fused to a GST tag. Human cytomegalovirus (HCMV), a member of the herpesvirus family, demonstrates cell specificity for virus assembly and release. CMVpp65 (UL83), in addition to being a major constituent of dense bodies, plays a critical role in cell-mediated immunity to HCMV infection. The majority of HCMV-seropositive individuals possess CD8+ cytotoxic T-lymphocyte responses directed against pp65, and the adoptive transfer of pp65-specific cytotoxic T lymphocytes isolated from HCMV-seropositive bone marrow donors to transplant recipients has been shown to confer protection against HCMV viremia and pneumonitis. These observations have provided support for the concept of development of pp65 vaccines for prevention of HCMV infection.

-20°C

12352202