CNOT1 Antibody

Cusabio

CNOT1 Antibody

20

ImmunoFluorescence, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

CNOT1

CCR4-NOT transcription complex subunit 1

AD-005, CDC39, HPE12, NOT1, NOT1H, VIBOS, CCR4-NOT transcription complex subunit 1, CCR4-associated factor 1, NOT1 (negative regulator of transcription 1, yeast) homolog, adrenal gland protein AD-005, negative regulator of transcription subunit 1 homolog

Rabbit

IgG

CCR4-NOT transcription complex subunit 1

Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity.

Human

-20°C or -80°C

41116161