CNOT4 antibody

GeneTex

CNOT4 antibody

9

WB: 1 - 2 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ELISA

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

CNOT4

CCR4-NOT transcription complex subunit 4

CCR4-associated factor 4; CCR4-NOT transcription complex subunit 4; CLONE243; E3 ubiquitin-protein ligase CNOT4; NOT4; NOT4 (negative regulator of transcription 4, yeast) homolog; NOT4H; potential transcriptional repressor NOT4Hp; RING-type E3 ubiquitin transferase CNOT4

Rabbit

IgG

CCR4-NOT transcription complex subunit 4

CNOT4 is a component of the CCR4-NOT transcription complex, a complex that is implicated in the repression of RNA polymerase II transcription. In the CCR4-NOT complex, CNOT4 acts as an E3 ubiquitin-protein ligase and interacts with a subset of E2 ubiquitin-conjugating enzymes through a unique C4C4 RING domain. This E3 ligase activity was shown to be dependent on the selective and specific interaction with the ubiquitin conjugating enzyme UbcH5B. In yeast, mutations in CNOT4 that prevented its interaction with the UbcH5B homolog UBC4 caused increased sensitivity to hydroxyurea, heat shock, and hygromycin B, suggesting that CNOT4 and UbcH5B are involved in stress response in vivo. Multiple isoforms of CNOT4 are known to exist.

Human, Mouse, Rat

-20°C or -80°C,2°C to 8°C

12352203